Integrating GABA and dopamine signals to regulate meal initiation

When you are feeling hungry, the brain takes the necessary steps toward consuming a meal. Many of these steps are not well known, but a new study published in the journal Metabolism by researchers at Baylor College of Medicine and the University of Texas Health Science Center at Houston reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake. The findings have implications for the development of improved therapies to manage obesity, a worldwide epidemic.

“It’s well known that serotonin, a neurotransmitter in the brain, can suppress food intake. This finding led to the development of drugs that interact with serotonin or its receptors to regulate food consumption and obesity,” said corresponding author Dr. Yong Xu, professor of pediatrics — nutrition and…

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