TOPLINE:
The genomic drivers of coronary artery disease (CAD) are associated with the presentation of acute coronary syndromes and the severity and burden of angiographic CAD; these drivers also predict the risk for adverse outcomes after angiography.
METHODOLOGY:
- Researchers conducted a retrospective cohort study to examine the association of genomic drivers of CAD with the severity of the condition and future outcomes in patients who underwent coronary angiography.
- They included 3518 participants with genomic data (median age, 64 years; 70.1% men; 89.6% White individuals) from a hospital-based biobank who underwent their first coronary angiography between July 2000 and August 2023 and were followed through October 2023.
- Pathogenic variants of causal genes of familial hypercholesterolemia, a high CAD polygenic risk score,…