Introduction
Asthma is a kind of heterogeneous disease usually characterized by chronic airway inflammation. It is the most common chronic disease in children and a major contributor to the high prevalence of chronic disease in children, as measured by school absences, emergency department visits, and hospitalizations.1 The majority of children with asthma are able to control their condition with standard therapy, but it is estimated to be difficult for 5–10% of children with severe asthma.2
Severe asthma is that uncontrolled despite adherence with optimized high-dose ICS-LABA therapy and treatment of contributory factors, or that worsens when high-dose treatment is decreased.3 Severe asthma represents only a minority of asthma patients, but a significant portion of the asthma disease burden comes from this group…