Introduction
The COVID-19 pandemic has posed unprecedented challenges to the global medical system. Severe cases often develop into acute respiratory distress syndrome (ARDS), multiple organ failure and death. In critically ill patients, serum albumin concentrations are significantly lower than in non-critically ill patients, and hypoalbuminemia is closely associated with adverse clinical outcomes, including an increased risk of mortality.1–3
Serum albumin is the most abundant protein in human plasma, accounting for approximately 50% to 60% of total plasma proteins. It possesses multiple physiological functions, maintaining colloid osmotic pressure while also exhibiting anti-inflammatory, antioxidant, and anticoagulant properties.4–6 These functions could be crucial for alleviating the common high inflammatory and…