Piotr Milkiewicz, MD, DSc, MRCP
Credit: Sonomed Szczecin
New research suggests fatigue is common in patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), underscoring the importance of quantifying this symptom in patients’ clinical workup and considering it in therapeutic decision-making.1
Leveraging data from 2 cohorts of patients with PBC and PSC recruited from the Medical Universities in Szczecin and Warsaw in Poland, the study found fatigue was more common among patients with PBC but disproportionately impacted females with PSC. Of note, fatigue was not modulated by disease duration and did not improve with response to ursodeoxycholic acid (UDCA) but was significantly associated with itch.1
“The etiology of fatigue in the setting of cholestatic conditions like PBC and PSC is…