Exploring the potential of cell-free RNA and Pyramid Scene Parsing Network for early preeclampsia screening | BMC Pregnancy and Childbirth

Ethical statement

This study was exempt from ethics approval by the Ethical Committee of Xi’an Jiaotong University as it involved the analysis of publicly available data from the Gene Expression Omnibus (GSE192902) database and did not involve direct interaction with human subjects or animal models.

Study design and prediction mechanism

To predict PE risk, we approached it as a data regression problem, creating a mapping between maternal plasma cfRNA profiles and probability vectors. Initially, we preprocessed the cfRNA sequencing data to filter out markers with significant differences between normotensive (NP) and preeclamptic (PE) groups. Based on the guidelines from the American College of Obstetricians and Gynecologists (ACOG), PE is defined as new-onset hypertension (systolic ≥ 140 mmHg or…