As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These mutations can give the cells a growth advantage, laying the foundation for developing serious health conditions. Now, scientists at The Jackson Laboratory (JAX) have not only discovered the mechanism that fuels their unchecked growth but have also found a way to stop it.
Led by Jennifer Trowbridge, professor and The Dattels Family Chair at JAX, the study reported today in the April 16 issue of Nature Communications reveals that a common aging-associated mutation in the gene Dnmt3a boosts the power-generating function of mitochondria in blood stem cells. This mutation allows the cells to make copies of themselves more readily than normal and creates fertile ground for the development of clonal…