TOPLINE:
The combination of remimazolam and ketamine for deep analgosedation during pulsed-field ablation for atrial fibrillation was associated with fewer adverse events than propofol-based methods, with the regimen significantly reducing hypoxemia and hypotension.
METHODOLOGY:
- Czech researchers conducted a prospective randomized controlled trial involving 127 patients (mean age, 62.9 years; 35.1% women) with an indication for catheter ablation for atrial fibrillation between October 2023 and September 2024.
- Patients were randomly assigned to one of the three groups:
- Propofol-opioid sedation (n = 42), which involved the intravenous administration of midazolam, sufentanil, and propofol boluses as needed during the procedure
- Continuous remimazolam-ketamine sedation (n = 43), which involved a loading dose of intravenous…