TOPLINE:
Only 5% of patients with trauma experienced significant hypoxemia within the first 8 hours of care, with no difference observed between restrictive and liberal oxygen strategies.
METHODOLOGY:
- This substudy of the randomized TRAUMOX2 trial included 60 adults with trauma injury (median age, 49 years; 75% men) who were randomly assigned to receive either a restrictive or liberal oxygen therapy during the first 8 hours after trauma in Denmark.
- Eligible patients had blunt or penetrating trauma and were expected to stay in the hospital for > 24 hours. Patients with carbon monoxide poisoning or cardiac arrest before randomization were excluded.
- The primary outcome was hypoxemia, defined as having arterial oxygen saturation of < 90% for at least 5 minutes, measured using continuous pulse oximetry.
- The median continuous…