In this study, multidomain lifestyle intervention resulted in favourable changes in participants’ dietary habits and physical activity, and part of the improvements remained also during the long-term post-intervention follow-up. Although no significant differences between the intervention and control groups were evident in other modifiable factors, we showed that, in the whole cohort, social and cognitive activities increased, and self-evaluated health and memory improved during the active study period but decreased thereafter. Alcohol use tended to decrease over time. Smoking decreased more in the intervention group during the intervention period, but this difference was not maintained in longer term. During the COVID-19 pandemic, frequency of participants’ physical and cognitive activities increased and so did…