A new study published in the American Journal of Health-System Pharmacy suggests there may be a connection between a GLP-1 receptor agonist (GLP-1 RA) drug, semaglutide (sold under brand names Ozempic, Wegovy and Rybelsus) and an unusual side effect: painful skin sensitivity known as allodynia.
The research focused on four patients who developed this symptom after their semaglutide dose was increased.
In each case, the reaction was rated as “probable” using the Naranjo scale, a tool used by clinicians to assess whether a drug likely caused a specific side effect. The scale scores reactions as doubtful, possible, probable, or definite.
GLP-1 RAs such as semaglutide are commonly used to manage type 2 diabetes and support weight loss.
Woman injecting her stomach with a needle.
These drugs are generally well tolerated,…