Summary: A new study finds that elevated cortisol levels in midlife are linked to increased brain amyloid deposition—a key marker of Alzheimer’s disease—specifically in post-menopausal women. Researchers tracked 305 cognitively healthy individuals over 15 years and discovered that high cortisol predicted amyloid buildup later in life, but only among women who had gone through menopause.
The findings suggest that hormonal changes may amplify cortisol’s harmful effects on brain health. No similar relationship was found in men or with tau protein, another Alzheimer’s marker.
Key Facts:
- Sex-Specific Risk: High midlife cortisol predicted Alzheimer’s risk only in post-menopausal women.
- Amyloid Link: Cortisol levels were associated with increased amyloid buildup, not tau.
- Prevention Potential: Findings suggest early…