Scientists at St. Jude Children’s Research Hospital found that, in neural development, the same set of proteins involved in cellular self-renewal can also facilitate differentiation with the right binding partner.
The fundamental processes that govern neural development are complex and, as findings by scientists at St. Jude Children’s Research Hospital demonstrate, the underlying driving forces can even appear conflicting. The TEAD family of proteins is thought to promote self-renewal and proliferation of progenitor cells in the brain. However, St. Jude researchers have discovered that these same proteins can also play a role in differentiation when they have a different binding partner. This discovery sheds light on the intricate mechanisms of neural…