New research has revealed how cellular senescence – the process in which aging cells change function – shapes human brain structure from development to old age, improving our understanding of brain ageing and neurodegenerative diseases.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered how cellular senescence – a biological process in which ageing cells change their function – is associated with human brain structure during both development and late life. The study demonstrates how molecular signatures of cellular senescence mirror brain volume and cortical organisation throughout life.
Decoding brain structure and cellular senescence
Understanding the structure of the human brain has always been a key challenge in neuroscience. While it is known that brain structure…