Specific genetic architecture in the gut microbial ecosystem can shape microbial composition in ways that are potentially relevant to the pathogenesis of celiac disease, according to a study published this month in Nature Genetics.
As MedCentral recently reported, although the community of micro-organisms in the gastrointestinal (GI) tract, also known as the gut microbiota, is associated with many diseases — and research suggests that genetic predisposition may play a role — no specific microbial species has been consistently shown to drive the progression of celiac disease, a GI condition characterized by the loss of gluten tolerance.
“Overall, the HUNT study is very fascinating, bringing to light the delicate interplay of genetic predisposition and the microbiome,” Susan S. Kais, MD, a…