Causal relationship between blood metabolomics and Female pattern hair

Introduction

Female pattern hair loss (FPHL), also known as androgenetic alopecia (AGA), is the most common type of non-scarring alopecia with rising prevalence and is characterized by progressive hair follicle (HFs) miniaturization with a subsequent decrease in hair density.

To date, the pathogenesis of FPHL is multifactorial and has not been completely elucidated. Recently, an increasing number of studies have underscored the robust correlation between AGA and human blood metabolites. A meta-analysis of AGA investigated the levels of serum total cholesterol, TG, and LDL cholesterol, indicating the importance of abnormal lipid profiles in AGA pathogenesis.1 Furthermore, contemporary multiple-omics research has revealed an intricate map of the primary and secondary…

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