The Egyptian Mohamed Elneny (ST 18 and 31m) and the English Eddie Nketiah (ST 25m) converted the goals for an Arsenal with a mix of starters and substitutes, at The Kassam Stadium in Oxford.
The London team will face Manchester City in the next round, which eliminated Chelsea on Sunday after the 4-0 win, with a goal from Argentine striker Julián Álvarez.
To define the 32nd. The finals remain to be played between Forest Green-Birmingham (suspended on January 7) and the rematches between Luton (1)-Wigan (1), Bristol City (1)-Swansea (1), Chesterfield (3)-West Bromwich (3), Liverpool (2)-Wolverhampton (2), Boreham Wood (1)-Accrington (1) and Cardiff (2)-Leeds (2). These matches will take place on January 17.
Arsenal is the maximum champion of the FA Cup, which has been held since the 1871-1872 season, with 14 championships and Liverpool (8) is the defending champion.