Column | Powerful new weight-loss drug may also ease knee pain, major study finds — Live Feedhttps://www.live-feeds.com/feed/column-powerful-new-weight-loss-drug-may-also-ease-knee-pain-major-study-findsContinuously updated, source-cited coverage. Retatrutide shows significant knee osteoarthritis pain relief in major clinical trialshttps://www.live-feeds.com/feed/column-powerful-new-weight-loss-drug-may-also-ease-knee-pain-major-study-findshttps://www.live-feeds.com/feed/column-powerful-new-weight-loss-drug-may-also-ease-knee-pain-major-study-finds#u201898Sun, 15 Nov 2026 06:51:32 +0000Eli Lilly's experimental triple-hormone drug retatrutide significantly reduced knee osteoarthritis pain and improved physical function in two Phase 3 clinical trials involving adults with obesity. The findings were presented at the American College of Rheumatology Convergence 2026. Retatrutide, which targets GLP-1, GIP, and glucagon receptors, is being studied for both weight loss and metabolic conditions. Researchers reported that some patients experienced near-complete resolution of chronic knee pain. The drug is not yet approved for any indication.Why it mattersOsteoarthritis is a lead