Keto diet cut liver fat by 67% in a clinical trial
A clinical trial found a ketogenic diet reduced liver fat by 67% after 4 to 5 months, significantly outperforming Mediterranean and plant-forward diets. While all three diets produced similar weight loss of approximately 10%, the ketogenic approach yielded greater improvements in hepatic insulin sensitivity and several glucose and insulin measures. Additionally, half of the ketogenic diet participants no longer met the criteria for prediabetes. These results suggest that the composition of a diet impacts liver health independently of total weight loss.
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- ✓ A ketogenic diet reduced liver fat by 67% in a clinical trial.
- ✓ Participants in the trial achieved approximately 10% weight loss.
- ✓ The ketogenic diet outperformed Mediterranean and plant-forward diets in reducing liver fat.
- ✓ Half of the participants on the ketogenic diet no longer met prediabetes criteria.
What changed
Trial data now specifies the 67% liver fat reduction occurred within 4 to 5 months and compared to a 45% reduction in Mediterranean and plant-forward diets.
Live updates
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Ketogenic Diet Outperforms Other Diets in Liver Fat Reduction
A clinical trial found a ketogenic diet reduced liver fat by 67% after 4 to 5 months, significantly outperforming Mediterranean and plant-forward diets. While all three diets produced similar weight loss of approximately 10%, the ketogenic approach yielded greater improvements in hepatic insulin sensitivity and several glucose and insulin measures. Additionally, half of the ketogenic diet participants no longer met the criteria for prediabetes. These results suggest that the composition of a diet impacts liver health independently of total weight loss.
Why it matters
Metabolic liver disease affects hundreds of millions of people globally. While weight loss generally improves cardiometabolic measures, researchers are investigating specific dietary and pharmacological interventions to prevent liver scarring and failure.
What is confirmed
- A ketogenic diet reduced liver fat by 67% in a clinical trial.
- Participants in the trial achieved approximately 10% weight loss.
- The ketogenic diet outperformed Mediterranean and plant-forward diets in reducing liver fat.
- Half of the participants on the ketogenic diet no longer met prediabetes criteria.
- Ketogenic, Mediterranean, and very-low-fat plant-forward diets all improved insulin sensitivity and cardiometabolic measures.
Still unconfirmed
- Mediterranean and plant-forward diets reduced liver fat by 45%.
- The protein EFHD1 triggers an out-of-place antiviral immune response that drives metabolic liver damage.
- A selective thyroid hormone receptor beta agonist reduces hepatic fat in adults with metabolic dysfunction-associated steatohepatitis.
What to watch next
- Long-term sustainability data for the 67% liver fat reduction beyond the 5-month mark.
- Clinical trial results for EFHD1 protein blocking as a treatment for liver scarring.
- Phase 3 trial results for thyroid hormone receptor beta agonists in treating MASH.
confidence 90%Sources used for this update (9)
- medicalxpress.com — Cancer's malignant remote control: How tumors reprogram liver fat metabolism to disarm immune cells
- www.news-medical.net — The scale told a similar story across three diets. The liver told a different one
- www.ibtimes.sg — Keto Diet Cuts Liver Fat by 67% After Just 4–5 Months, Clinical Trial Finds
- www.earth.com — This popular diet reduced liver fat by two-thirds and helped many participants overcome prediabetes
- www.earth.com — Three diets caused equal weight loss, but one had a clear advantage for the liver
- www.news-medical.net — Blocking a key protein protects against metabolic liver damage
- www.medscape.com — Thyroid Hormone Receptor Beta Agonist Reduces Liver Fat in MASH
- www.earth.com — Keto diet delivers surprising health benefits beyond weight loss
- www.scientificamerican.com — Could GLP-1 weight-loss drugs help you live longer?
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Keto diet cuts liver fat by 67% in clinical trial
A clinical trial found that a ketogenic diet reduced liver fat by 67%. The keto diet also excelled at reversing prediabetes and fatty liver. Researchers compared the keto diet to Mediterranean and low-fat diets, finding it superior in one key health measure. The study's findings suggest that a keto diet may be an effective treatment for liver and metabolic health.
Why it matters
The ketogenic diet has been a topic of interest for its potential health benefits, particularly in regards to weight loss and metabolic health. Fatty liver disease is a growing concern, and current treatments often focus on lifestyle changes. The keto diet's high-fat, low-carbohydrate approach has been shown to have positive effects on liver health.
What is confirmed
- A ketogenic diet reduced liver fat by 67% in a clinical trial.
- The keto diet excelled at reversing prediabetes and fatty liver.
- The keto diet was superior to Mediterranean and low-fat diets in one key health measure.
What to watch next
- Further clinical trials to confirm the keto diet's effectiveness
- Long-term studies on the keto diet's sustainability and potential side effects
- Comparisons of the keto diet to other low-carb diets
confidence 90%Sources used for this update (5)
- Science Daily — Keto diet cut liver fat by 67% in a clinical trial
- News-Medical — Ketogenic diet excels at reversing prediabetes and fatty liver
- Scientific American — Is the keto diet better than the Mediterranean? New clinical trial reveals health benefits
- ScienceAlert — Scientists Pitted Keto Against Mediterranean And Low-Fat Diets. Keto Won on One Clear Health Measure.
- New York Post — Surprising study names which diet beats Mediterranean and low-fat diets for liver and metabolic health
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