Why weight-loss drugs don’t work for some people
Some people do not respond to current weight-loss strategies, particularly those relying on GLP-1 agonists that suppress hunger. Research into the compound TOFA suggests an alternative method by altering lipid metabolism and energy expenditure to reduce fat. This approach targets biological mechanisms other than appetite control, offering a potential path for those unresponsive to traditional hunger-suppressing medications.
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- ✓ GLP-1 agonists, such as Ozempic, can trigger hair loss in some users.
- ✓ Some individuals do not respond to traditional weight-loss strategies using GLP-1 agonists.
What changed
Leslie Mann revealed Judd Apatow's experience with Ozempic, where he intentionally gained weight despite the medication's intended effect.
Live updates
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Weight-loss drugs' ineffectiveness sparks search for alternatives
Some people do not respond to current weight-loss strategies, particularly those relying on GLP-1 agonists that suppress hunger. Research into the compound TOFA suggests an alternative method by altering lipid metabolism and energy expenditure to reduce fat. This approach targets biological mechanisms other than appetite control, offering a potential path for those unresponsive to traditional hunger-suppressing medications.
Why it matters
The limitations of current weight-loss strategies have sparked interest in alternative approaches. GLP-1 agonists, such as Ozempic, have been widely used but do not work for everyone. The search for new methods is driven by the need to help individuals who do not respond to traditional treatments.
What is confirmed
- GLP-1 agonists, such as Ozempic, can trigger hair loss in some users.
- Some individuals do not respond to traditional weight-loss strategies using GLP-1 agonists.
Still unconfirmed
- Judd Apatow likes to "override" the feeling Ozempic gives him to stop eating.
What to watch next
- Further research on TOFA's effectiveness in humans
- Long-term studies on Ozempic's side effects
- Development of alternative weight-loss medications
confidence 60%Sources used for this update (4)
- www.eonline.com — Leslie Mann Reveals Why Judd Apatow Intentionally Gained Weight on Ozempic
- consent.yahoo.com — “Sex and relationships seem a waste of time”: Inside the popular 'Godzilla' jab and its worrying side effects
- au.lifestyle.yahoo.com — Why Your Hair Might Be Thinning on a GLP-1 Drug—and What To Do About It
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Research explores non-appetite pathways for weight loss
Current weight loss strategies often rely on GLP-1 agonists that suppress hunger, but these do not work for everyone. Research into the compound TOFA suggests an alternative method by altering lipid metabolism and energy expenditure to reduce fat. This approach targets biological mechanisms other than appetite control, offering a potential path for those unresponsive to traditional hunger-suppressing medications. While TOFA results are currently limited to high-weight mice, the discovery indicates that weight management can be achieved through metabolic changes rather than just caloric restriction.
Why it matters
Most modern weight-loss drugs target the brain to reduce food intake. TOFA represents a shift toward metabolic regulation. This distinction is critical for patients who experience minimal results from appetite-based therapies.
Still unconfirmed
- SodaSlim is marketed as a metabolic support dietary supplement, though its statements are not evaluated by the FDA.
What to watch next
- Human clinical trials for TOFA
- FDA evaluation of metabolic support supplements
- Comparative studies between GLP-1 agonists and lipid metabolism modifiers
confidence 70%Sources used for this update (7)
- www.gq.com — How to Lose Body Fat the Smart Way
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TOFA compound shows fat loss potential in mice
Research into a decades-old compound called TOFA indicates it can reduce fat in high-weight mice by changing energy expenditure and lipid metabolism. Unlike common weight-loss medications, TOFA does not work by curbing appetite. This discovery offers a potential alternative pathway for weight management that bypasses the hunger-suppression mechanisms found in GLP-1 agonists. While these results are limited to animal models, they highlight different biological methods for achieving weight loss beyond the current focus on appetite control.
Why it matters
The medical community is currently debating the efficacy and side effects of GLP-1 agonists. This occurs as South Africa introduces generic semaglutide to lower costs and combat black market sales. Researchers are seeking alternatives to address patients who do not respond to existing treatments.
What is confirmed
- TOFA helped high-weight mice lose fat by altering energy expenditure and lipid metabolism.
What to watch next
- Clinical trials testing TOFA efficacy in humans
- Updates on pending generic weight-loss drug applications from Aspen Pharmacare
confidence 90%Sources used for this update (6)
- ca.style.yahoo.com — 75 Medical Field Workers Share Things They Wish More People Understood
- cen.acs.org — Decades-old compound drives weight loss without curbing appetite in mice
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Generic GLP-1 Drugs Enter South African Market
South Africa introduced its first generic semaglutide injection in August 2026 to lower the cost of blockbuster weight-loss and diabetes medications. While increased competition aims to make these drugs accessible to public sector patients, officials question if price drops will be sufficient to dismantle a thriving black market. This development follows ongoing debates regarding the efficacy of GLP-1 agonists and their association with severe gastrointestinal complications. Additional generic applications remain pending, including one from Aspen Pharmacare, as patents for brand-name drugs expire.
Why it matters
GLP-1 agonists have become standard treatments for obesity and diabetes but vary in effectiveness among patients. High costs have historically driven a dangerous illicit trade in these medications. The shift toward generics may alter patient access and market dynamics.
What is confirmed
- South Africa's first generic semaglutide injection arrived in August 2026.
- Generic versions of weight-loss and diabetes drugs are entering the South African market as patents expire.
Still unconfirmed
- Aspen Pharmacare has a pending application for a generic weight-loss drug.
What to watch next
- Approval of the thirteen pending generic drug applications in South Africa.
- Data on whether generic pricing reduces black market activity in the region.
confidence 90%Sources used for this update (9)
- www.news24.com — Generic weight loss drugs are in SA. Will they kill the black market?
- medicalxpress.com — How much of a cancer drug is too much? Patients, researchers challenge FDA-approved dosages
- ca.style.yahoo.com — What Are Weight Loss Patches, and Do They Work?
- www.newscientist.com — Will muscle-boosting meds be the next big thing after GLP-1 drugs?
- mg.co.za — The first generic weight loss drug hit SA in August — with many expected to follow. Will it be enough to kill the black market?
- www.ewn.co.za — Generic weight loss drug on SA's shelves, says health writer
- www.eonline.com — Jelly Roll Confirms NSFW Detail About His Penis After Weight Loss
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Weight-loss drug ineffectiveness sparks concern
Some individuals are not responding to weight-loss medications, sparking concern and debate. Dr. Mehmet Oz, Centers for Medicare & Medicaid Services administrator, discussed the issue on 'Face the Nation with Margaret Brennan' on Aug. 23, 2026. The medications, including GLP-1 agonists, have been successful in treating obesity and diabetes but have also been linked to severe gastrointestinal complications and other side effects.
Why it matters
The issue of weight-loss drug ineffectiveness and side effects is significant as it affects the treatment of obesity and diabetes. GLP-1 agonists have been widely used for weight loss and glucose control. However, reports of severe side effects have raised concerns about their safety and efficacy.
What is confirmed
- GLP-1 agonist users have experienced severe gastrointestinal complications and hair loss.
- Weight-loss medications have been successful in treating obesity and diabetes.
Still unconfirmed
- Some speculate that weight-loss injections or specific diets are responsible for increased flatulence at raves in Ibiza.
What to watch next
- Further research on the side effects of GLP-1 agonists
- FDA updates on the safety and efficacy of weight-loss medications
- Long-term studies on the effectiveness of weight-loss drugs
confidence 80%Sources used for this update (5)
- www.cbsnews.com — Transcript: Dr. Mehmet Oz on "Face the Nation with Margaret Brennan," Aug. 23, 2026
- oncodaily.com — Multiple Myeloma in 2026: Comprehensive Clinical Update
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Weight-loss drug side effects linked to Ibiza odor complaints
TikTok users and holidaymakers in Ibiza are reporting a rise in foul smells at raves, sparking a debate over the cause. Some speculate that weight-loss injections, specific diets, or other drugs are responsible for the increased flatulence on the island. This follows previous reports of GLP-1 agonist users experiencing severe gastrointestinal complications, hair loss, and other life-altering side effects despite the medications' success in treating obesity and diabetes.
Why it matters
GLP-1 agonists like Ozempic and Wegovy are widely used for weight management and diabetes. While effective for many, a subset of patients has filed lawsuits over severe adverse reactions.
Still unconfirmed
- TikTokers are debating if weight-loss injections, diet, or drugs are causing a flatulence problem in Ibiza.
What to watch next
- Medical confirmation of the link between GLP-1 agonists and the reported odors in Ibiza
- New data on gastrointestinal side effects from GLP-1 agonist clinical trials
confidence 50%Sources used for this update (9)
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Weight-loss drugs' limited efficacy sparks concern
Some patients taking GLP-1 agonist drugs like Ozempic and Wegovy for weight loss and diabetes management report severe side effects, prompting lawsuits and growing skepticism about their effectiveness. Despite their popularity, a subset of users experience life-altering gastrointestinal complications, hair loss, and other issues, leading to questions about their benefits and risks. The medications have been revolutionary for many with obesity and chronic health issues, but unwanted side effects are a concern.
Why it matters
The GLP-1 agonist drugs have been widely adopted for diabetes and obesity treatment, but concerns about their safety and efficacy are mounting. Patients are filing lawsuits against manufacturers, alleging failure to warn about severe side effects. The drugs' popularity has also led to a black market for peptides in some countries.
What is confirmed
- GLP-1 medications have been life-changing for many people with obesity and chronic health issues.
- The Charles George VA Medical Center is recruiting veterans for a nationwide clinical trial testing semaglutide.
Still unconfirmed
- Tirzepatide has been linked to hair loss.
What to watch next
- Results from the national GLP-1 trial testing semaglutide for alcohol use disorder
- Further research on the causes of severe side effects in GLP-1 medication users
- Regulatory actions against manufacturers of GLP-1 agonist drugs
confidence 80%Sources used for this update (4)
- wlos.com — Asheville VA recruits veterans for national GLP-1 trial to treat alcohol use disorder
- www.psychologytoday.com — When Weight Loss Meds Flatten More Than Appetite
- lovinmalta.com — Inside Malta’s Weight-Loss Drug Boom And Peptide Black Market
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Lawsuits target GLP-1 manufacturers over severe side effects
Patients are filing mass tort lawsuits against manufacturers of GLP-1 agonist drugs including Ozempic, Wegovy, and Mounjaro. Plaintiffs allege these companies failed to warn users about life-altering gastrointestinal complications and other severe side effects. Recent research also links tirzepatide to hair loss. These legal challenges emerge as the drugs maintain widespread popularity for diabetes and obesity management, but a growing number of users report that the medications have caused significant health crises rather than the promised benefits.
Why it matters
GLP-1 receptor agonists were initially designed for diabetes but expanded into weight loss and potential treatments for alcohol cravings. While many users see weight reduction, others have reported psychological setbacks and deaths. These new legal actions focus on the transparency of safety profiles provided by manufacturers.
Still unconfirmed
- Eli Lilly failed to adequately warn patients about severe gastrointestinal complications and stomach paralysis risks associated with Zepbound.
- Research suggests a significant link between the GLP-1 medication tirzepatide and hair loss.
What to watch next
- Court rulings on the mass tort lawsuits against GLP-1 manufacturers
- Clinical data confirming the link between tirzepatide and hair loss
confidence 70%Sources used for this update (6)
- www.thetechedvocate.org — Zepbound Lawsuits: The Hidden Stomach Paralysis Risk Eli Lilly Didn’t Tell You About?
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- www.glamour.co.za — The link between GLP-1 medications and hair loss: What you need to know
- euroweeklynews.com — Dr Google is seeing you now: The real risks of online self-diagnosis
- www.thetechedvocate.org — Millions on Ozempic: The Hidden Truth About Severe Side Effects You Need to Know
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GLP-1 Drugs Linked to Eating Disorder Relapse and Potential Addiction Treatment
GLP-1 receptor agonists are expanding beyond weight loss into potential treatments for alcohol cravings, though some users report severe psychological setbacks. Gracie McGraw stated that using Ozempic caused her eating disorder to return, describing the experience as one of the worst things she has done for herself. While doctors report that these medications often stop food from occupying a patient's mind, reports of hundreds of deaths highlight unseen dangers. Market access is expanding through providers like Amazon Pharmacy and the limited release of unapproved retatrutide by Lilly.
Why it matters
These medications mimic hormones that regulate blood sugar and appetite. The United States and New Zealand are the only high-income countries allowing direct-to-consumer advertising for these prescription drugs.
What is confirmed
- GLP-1 medications are available in brand-name and compounded forms as both pills and injections.
- The United States and New Zealand are the only developed nations that permit direct-to-consumer advertising of prescription medications.
- Amazon Pharmacy is a provider offering GLP-1 medications under a program for $50.
Still unconfirmed
- Hundreds of weight-loss drug deaths have been reported.
- GLP-1 agonists may significantly reduce heavy drinking and alcohol cravings.
- Lilly is expanding access to unapproved retatrutide for selected patients.
What to watch next
- Clinical trial results confirming the efficacy of GLP-1 drugs for alcohol addiction.
- Regulatory decisions regarding the approval of retatrutide.
- Data on the frequency of eating disorder relapses associated with GLP-1 use.
confidence 80%Sources used for this update (18)
- www.aol.com — Phil Collins Details His Organs “Seizing Up” During Alcohol Addiction
- www.thetechedvocate.org — This Breakthrough Weight-Loss Drug Reduced Heavy Drinking. Scientists Think They Know Why
- www.wjhg.com — MEDICAL MONDAY: GLP-1 medications...What doctors want you to know before starting a weight loss shot
- euroweeklynews.com — The GLP-1 Revolution: The weight-loss drugs changing lives
- www.aol.com — Tim McGraw's Daughter Gracie Says Ozempic Brought Back Eating Disorder
- www.medscape.com — Retatrutide Expanded Access Draws Mixed Clinician Views
- eu.indystar.com — 'Hate to go out this way.' AZ icon Sam Meranto in bitter family fight
- www.newsweek.com — How to Get GLP-1 Weight Loss Drugs for $50: List of Major Pharmacies
- www.tpr.org — Everyone's talking about hormone therapy for menopause. Should I be on it?
- markets.businessinsider.com — Calocurb Founder and CEO Sarah Kennedy Shares New Clinical Research That Is Changing the GLP-1 Weight Loss Conversation on YourUpdateTV
- www.sciencemediacentre.co.nz — Why does NZ allow weight-loss drug billboards? – Expert Reaction
- www.thetechedvocate.org — Hundreds of Weight-Loss Drug Deaths Reported: The Unseen Dangers of GLP-1 Medications
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Unsupervised Use of GLP-1 Drugs Increases Health Risks
Patients are increasingly using GLP-1 medications like Ozempic and Wegovy as weight loss shortcuts without medical supervision. This trend bypasses safety protocols designed to protect users from disrupting complex bodily systems. While these drugs offer rapid results for some, the lack of professional oversight increases the risk of dangerous side effects. Public discourse around the medications continues to fluctuate between medical application and cosmetic use, as seen in social media responses to weight-related criticism.
Why it matters
GLP-1 receptor agonists target biological and genetic factors to reduce weight. While some users face insurance barriers or lifelong dependency, others seek the drugs outside clinical guidelines. This shift highlights a tension between therapeutic use and the desire for quick aesthetic changes.
Still unconfirmed
- Alabama Barker stated she intends to use the highest dose of Ozempic after facing criticism over her appearance.
What to watch next
- Medical data on health outcomes for patients using GLP-1s without supervision
- Regulatory changes regarding the prescription of weight loss drugs for non-medical use
confidence 70%Sources used for this update (4)
- www.thetechedvocate.org — The Alarming Truth About Weight Loss Drugs: Why Millions Are Risking Everything
- ca.news.yahoo.com — Alabama Barker Threatens to Go on "Highest Dose" of Ozempic
- www.hollywoodreporter.com — Charlie Hunnam Adopted Kittens While Filming ‘Monster’ to Decompress From “Darkest Realm” of Playing Ed Gein
- www.aol.com — If You're Doing This In Your Sleep, It's Time To See A Doctor
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Weight-loss drugs show varied results, expanding uses and concerns
Weight-loss drugs like GLP-1 receptor agonists show varying results based on individual biology and genetics. Medicare now covers select weight-loss drugs for $50 per month, but older adults are advised to weigh the risks. New studies suggest oral GLP-1 drugs may curb food cravings and help treat alcohol use disorder. Despite their promise, users face challenges including insurance hurdles and potential lifelong medication use.
Why it matters
The effectiveness of weight-loss drugs has been a topic of interest as prescription rates surge in the US and Australia. GLP-1 receptor agonists, such as Ozempic and Wegovy, have shown promise in aiding weight loss, but individual results vary. The medications' potential benefits and risks are being closely examined, particularly for older adults.
What is confirmed
- Medicare covers select weight-loss drugs for $50 per month.
- GLP-1 receptor agonists show varying weight loss results based on individual biology and genetics.
- Oral GLP-1 drugs may curb food cravings through unique brain pathways.
- Oral GLP-1 drugs may help treat alcohol use disorder.
Still unconfirmed
- An unapproved weight-loss drug, Retatrutide, is purportedly a longevity hack.
What to watch next
- Further studies on the long-term effects of GLP-1 receptor agonists
- Medicare's review of coverage for weight-loss drugs
- FDA approval of new weight-loss medications
confidence 75%Sources used for this update (7)
- www.foodnavigator.com — From food noise to alcohol cravings: The expanding promise of oral GLP-1s
- www.aarp.org — Medicare Now Covers Some Weight Loss Drugs — but Older Adults Should Weigh the Risks
- www.elle.com — Biohackers Think Retatrutide Will Be Bigger Than Ozempic. Does the Science Check Out?
- consent.yahoo.com — The Weight-Loss Drug Biohackers Now Swear Extends Your Life
- www.aol.com — GLP-1 envy: What to do when Book Club starts to look “smaller”
- sports.yahoo.com — Mania Mailbag: Who Will UFC Snag From MVP Next?
- tucson.com — Why Medicare consumers could see higher Part D premiums in 2027
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Weight-loss drugs show varied results, new uses explored
Weight-loss drugs like GLP-1 receptor agonists show varying results based on individual biology and genetics. Medicare now covers select weight-loss drugs for $50 per month, but older adults must consider risks and side effects. Researchers explore new uses, including curbing food cravings and treating alcohol use disorder.
Why it matters
The effectiveness of weight-loss drugs like Ozempic and Wegovy varies among individuals, and users face challenges including insurance hurdles and potential lifelong medication use. Recent developments in GLP-1 drugs have sparked interest in their potential applications beyond weight loss.
What is confirmed
- Medicare covers select weight-loss drugs for $50 per month.
- GLP-1 receptor agonists show varying weight loss results based on individual biology and genetics.
- Oral GLP-1 drugs may curb food cravings through unique brain pathways.
- Oral GLP-1 drugs could help treat alcohol use disorder.
Still unconfirmed
- An unapproved weight-loss drug, Retatrutide, is purportedly a longevity hack.
What to watch next
- Further research on oral GLP-1s' benefits and risks
- Medicare Part D premium changes in 2027
- FDA approval and regulation of new weight-loss drugs
confidence 75%Sources used for this update (7)
- www.foodnavigator.com — From food noise to alcohol cravings: The expanding promise of oral GLP-1s
- www.aarp.org — Medicare Now Covers Some Weight Loss Drugs — but Older Adults Should Weigh the Risks
- www.elle.com — Biohackers Think Retatrutide Will Be Bigger Than Ozempic. Does the Science Check Out?
- consent.yahoo.com — The Weight-Loss Drug Biohackers Now Swear Extends Your Life
- www.aol.com — GLP-1 envy: What to do when Book Club starts to look “smaller”
- sports.yahoo.com — Mania Mailbag: Who Will UFC Snag From MVP Next?
- tucson.com — Why Medicare consumers could see higher Part D premiums in 2027
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GLP-1 Weight-Loss Drugs: Efficacy and Social Impact
GLP-1 receptor agonists like Ozempic and Wegovy cause varying weight loss results based on individual biology and genetics. Recent data shows a surge in prescription rates in the US and Australia. Users face ongoing challenges including insurance hurdles and potential lifelong medication use.
Still unconfirmed:
- Prescription rates for GLP-1 drugs increased nearly tenfold in Australia since 2020.
- GLP-1 prescriptions quadrupled in the US.
- GLP-1 drugs may shift social dynamics and open new career opportunities for women.
- Users are facing insurance challenges and side effects.
- Some users may need to take GLP-1 medications for life.
- Health conditions related to weight gain have risen despite the use of weight-loss jabs.
confidence 70%Sources used for this update (6)
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- This One Drug Is Quietly Reshaping Women’s Lives and Relationships
- The Unseen Cost: 8 Ways GLP-1 Weight Loss Effects Are Reshaping Lives Beyond the Scale
- Success stories and setbacks: What it’s like to take GLP-1
- The diabetes crisis being masked by skinny jabs
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Weight-Loss Drug Efficacy and Individual Variation
GLP-1 receptor agonists like Ozempic and Wegovy slow digestion and increase insulin production. Weight loss varies by patient biology, genetics, and habits. Some users lose over 20% of their body weight while others see almost no results.
confidence 100%Sources used for this update (4)
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Genetic and Biological Factors Influence GLP-1 Drug Efficacy
GLP-1 receptor agonists like Ozempic and Wegovy mimic a hormone to slow digestion and increase insulin production. While some users lose over 20% of their body weight, others see almost no results. Response varies based on a patient's biology, genetics, and habits.
What's confirmed:
- Ozempic and Wegovy are GLP-1 receptor agonists that mimic the glucagon-like peptide 1 hormone.
- These medications slow digestion and stimulate the body to produce more insulin.
Still unconfirmed:
- Researchers are investigating if drugs like Mounjaro, Ozempic, and Wegovy can treat arthritis or cancer.
confidence 90%Sources used for this update (9)
- The Ozempic dilemma: Balancing demand, supply, and patient safety in a ...
- Millions are losing weight on Ozempic and Wegovy — here's what an ...
- Some people lose over 20% of their body weight on Ozempic. Others lose ...
- Could GLP-1 Weight Loss Drugs Also Treat or Prevent Chronic Diseases?
- Why Ozempic Fails Some Patients | Personalized GLP-1 Solutions - PlexusDx
- Why Semaglutide Isn't Working: Resistance & Solutions | PlexusDx
- Health - Scientific American
- Ethical Dilemmas in Weight Loss Medications: Informed Consent, Misuse ...
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GLP-1 Weight-Loss Drug Efficacy and New Biotech Trends
GLP-1 receptor agonists typically lead to a 15% reduction in body fat, though results vary by genetics and lifestyle. New biotech developments now focus on medications that preserve muscle mass during fat loss. Some patients face challenges obtaining these drugs due to insurance coverage issues.
Still unconfirmed:
- The FDA granted a well-connected 79-year-old early access to a new Eli Lilly drug.
- Biotech companies are developing drugs to help users maintain muscle while losing fat.
- Some patients struggle to get insurance coverage for GLP-1 medications.
confidence 70%Sources used for this update (6)
- Weight loss without muscle loss? The next generation of drugs is testing the...
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- Trouble getting weight loss drugs covered by insurance? Here's what to know
- Is Trump on an Experimental Weight Loss Drug? An Investigation.
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Understanding GLP-1 Weight-Loss Drug Non-Response
GLP-1 receptor agonists like Ozempic and Wegovy generally cause users to lose up to 15% of body fat. However, a significant portion of users do not respond to these medications. Effectiveness varies based on genetics, lifestyle, and medical adherence.
What's confirmed:
- GLP-1 receptor agonists such as Ozempic and Wegovy can lead to an average body fat loss of 15%.
- These medications were originally created to help patients with type 2 diabetes manage blood sugar.
- GLP-1 drugs improve insulin sensitivity and stimulate insulin secretion when blood levels are elevated.
Still unconfirmed:
- Between 10% and 30% of GLP-1 drug users may be non-responders.
- Roughly 10% of people may carry specific genetic variants that make GLP-1s less effective.
- Factors influencing Wegovy effectiveness include treatment duration, lifestyle modifications, medication adherence, and underlying medical conditions.
confidence 80%Sources used for this update (20)
- Losing weight with a GLP-1? Here's how to preserve your muscle mass.
- Why weight-loss drugs don’t work for some people
- Are Indians using weight loss drugs correctly? Gurugram surgeon warns your unregulated GLP-1 use can backfire
- 4 rules to Protect Muscle, Bones, and Brain Health When Using Ozempic
- Beyond GLP-1s: The next chapter of obesity care
- Barbara Intermill, On Nutrition: Nutrition matters for GLP-1 users
- Your GLP-1 medication: Building healthy habits for lasting results
- Are Weight Loss Medications Right for You? Pros and Cons of GLP-1s
- GLP-1 companion supplements and post-medication nutrition tap metabolic health demand
- The missing piece in medical weight loss: Why behavioral support is crucial for long-term success
- Why weight‑loss drugs don't work for some people
- Why weight‑loss drugs don't work for some people - Medical Xpress
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