The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more
Pereira, F. A., Qiu, Y., Zhou, G., Tsai, M. J. & Tsai, S. Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 13(8), 1037–1049 (1999). Google Scholar Pereira, F. A., Qiu, Y., Tsai, M. J. & Tsai, S. Y. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): Expression during mouse … Read more
Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers. This framework could improve the accuracy of precision oncology by more reliable prioritization of VUS. Comprehensive genomic profiling (CGP) enables comprehensive detection of … Read more
Autism has a significant and enduring sex bias, with roughly four boys diagnosed for every girl. For many years, experts have believed this disparity arises primarily from diagnostic inequities because much of autism research – and the screening tools that grew out of it – has historically focused on boys, effectively setting a male standard … Read more
A sweeping new review shows how disruptions in the gut microbiome may fuel obesity, insulin resistance, and cardiovascular risk, while pointing to diet and other microbiome-focused strategies that could help restore metabolic balance. Integrative mechanistic framework linking gut dysbiosis to systemic metabolic dysfunction. Arrows indicate the progression of events from exogenous and host-related factors to … Read more
A new study by UCLA Health published in Cell presents a major advancement in the future of personalized medicine by pinpointing new connections between people’s genes, disease risk and medicine response by using a clinically well-characterized and diverse population-represented biobank. By analyzing genetic data and electronic health records from 93,936 participants in the UCLA ATLAS … Read more
Newswise — New research published in Nature Cardiovascular Research reveals that heart failure and atrial fibrillation share underlying genetic and molecular mechanisms, suggesting that the two cardiovascular conditions may be less distinct than previously thought. Two serious heart conditions that often coexist Heart failure occurs when the heart muscle is damaged and unable to pump … Read more
In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of “younger” brain structure in undamaged regions as they adapt to injury. … Read more
UCLA study finds that small cell neuroendocrine tumors depend on a specific protein to grow, offering a potential path for new treatments. RT’s Three Key Takeaways: Genetic Dependency Identified: Researchers found that small cell neuroendocrine cancers, including lung and prostate tumors, become highly dependent on the E2F3 protein after losing the protective RB gene. Halting … Read more
Newswise — Imagine a tiny superhero inside every cell of your body whose job is to stop damaged cells before they turn dangerous. That superhero is a gene called TP53, and for decades scientists have known it as the “guardian of the genome.” But what happens when the guardian breaks? A recent study led by Asst. Prof. Caner … Read more