in vitro

Researchers develop T cell growth method that enhances cancer-fighting ability in melanoma model

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Researchers have developed a new method to grow T cells that have greater longevity and can more efficiently destroy cancer cells in mouse models of melanoma compared to those grown in traditional growth media Study: Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy. Image Credit: ART-ur/Shutterstock.com … Read more

Fluoxetine not effective for COVID-19 patients

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Evidence shows weak antiviral activity and no improvement in symptom outcomes. Study: Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV). Image Credit: luchschenF/Shutterstock.com In a recent study published in eClinicalMedicine, researchers characterized the antiviral activity of a selective serotonin reuptake inhibitor (SSRI), fluoxetine, in early coronavirus disease 2019 (COVID-19). … Read more

Study reveals key antioxidant differences and health benefits

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Scientists show how Manuka and Ohia Lehua honey differ in their antioxidant potential, showing that while Manuka honey boasts higher phenolic content, Ohia Lehua honey excels in reducing oxidative stress and promoting antioxidant defenses. Study: Phytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey. Image Credit: Valentyn Volkov / Shuttersotck.com The use of … Read more

Gut microbes revealed as hidden drivers of aging and cellular decline

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New research reveals the gut microbiota’s surprising role in aging and highlights promising therapies to counteract its effects on cellular health. Study: Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence. Image Credit: Tatiana Shepeleva / Shutterstock A recent study published in the journal Nature Aging investigated the role of gut microbiota-derived phenylacetylglutamine (PAGln) in driving cellular senescence and … Read more

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers.

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Insilico Medicine Advances AI-Powered Drug Discovery with Promising New Candidate for MTAP-Deleted Cancers Insilico Medicine (‘Insilico’), a leading clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, has announced a significant milestone. The company has nominated ISM1745, a novel MTA cooperative PRMT5 inhibitor, as a preclinical candidate (PCC) for the treatment of MTAP-deleted cancers. … Read more