laboratory

Genomic study advances prioritization of variants in cancer diagnostics

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Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers. This framework could improve the accuracy of precision oncology by more reliable prioritization of VUS. Comprehensive genomic profiling (CGP) enables comprehensive detection of … Read more

New urine test shows which UTI antibiotic works in under six hours

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A new direct-from-urine test could help doctors choose the right antibiotic for UTIs on the same day, potentially improving patient outcomes while reducing delays that can fuel resistance and serious complications. Patients with urinary tract infections (UTIs) could receive the right antibiotic far sooner, thanks to a new test that produces results within hours rather … Read more

Study reveals how inflammation disrupts lymph node structure in lymphoma

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In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses. Lymph nodes are highly organized command centers of the immune system. Within these structures, immune cells … Read more

ATLAS platform enables realistic study of metastatic cancer clusters

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Metastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they travel through the bloodstream. Rice University bioengineers report a new platform designed to streamline one of the … Read more

Novel bacteriophage offers a promising biocontrol solution against foodborne Salmonella

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Researchers from China have identified a novel bacteriophage that offers a highly promising “green” biocontrol solution against foodborne Salmonella. The study was published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. This study was conducted to address the severe challenges posed by antimicrobial-resistant Salmonella to global food safety and public … Read more

Lysosomal storage of drugs may influence cancer treatment outcomes

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One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, from a multi-disciplinary team led by Dr Louise Fets at the LMS, has mapped the distribution of a type of targeted treatments, known as PARP inhibitors, using advanced imaging techniques and patient ovarian tumour samples. The research reveals that build up of these drugs in lysosomes – small compartments inside cells that normally act as “recycling centres” – can trap and … Read more

New method creates longer lasting CAR T cells for cancer therapy

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A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more

Adding three simple amino acids boosts mRNA and CRISPR delivery

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Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution. Researchers are racing to use them to ferry therapeutic mRNA into cells for cancer therapies and treatments for inflammatory diseases, as well as delivering … Read more

New protein target for safer lung cancer therapy

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Researchers at the University of Gothenburg have identified a protein linked to an increased risk of metastasis and recurrence in lung cancer. The findings are presented in a study that paves the way for new precision medicine approaches, particularly for older patients. Lung cancer primarily affects older individuals. Despite this, many laboratory studies rely on … Read more

Study finds keto diet strengthens the brain against epilepsy

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Published in The Lancet Neurology, a new review from the University of Colorado Anschutz in collaboration with UT Southwestern Medical Center, offers the latest scientific explanations for why ketogenic diets reduce seizures in people with epilepsy. The paper brings together insights from both laboratory discoveries and real‑world patient outcomes, showing that ketogenic diets do far more … Read more