Key Takeaways: The brain relies on long-distance connections, but scientists have lacked precise tools to control specific pathways. This study introduces a new method to selectively turn individual brain connections on or off with high precision. The approach brings us closer to understanding how human brain networks function, and how their disruption leads to disease. … Read more
Newswise — Patients with psychosis have a disrupted connection to reality, often suffering from delusions and hallucinations. These symptoms have been thought to arise from the same brain processes, but a new Yale study upends this long-held belief. The new study examined the natural progression of delusions and hallucinations in two large groups of adolescents … Read more
Newswise — In vivo cell type-specific genetic recombination based on the Cre-loxP system has contributed to the understanding of biological processes and diseases. Neuronal nuclei (NeuN)/RBFOX3 is a widely used mature neuron marker in developmental biology and neuroscience. Here, we generated Rbfox3-improved Cre (iCre) knock-in mouse model and investigated the effect of iCre knock-in into the Rbfox3 gene … Read more
Newswise — In vivo cell type-specific genetic recombination based on the Cre-loxP system has contributed to the understanding of biological processes and diseases. Neuronal nuclei (NeuN)/RBFOX3 is a widely used mature neuron marker in developmental biology and neuroscience. Here, we generated Rbfox3-improved Cre (iCre) knock-in mouse model and investigated the effect of iCre knock-in into the Rbfox3 gene … Read more
While manganese is essential in many bodily functions, both deficiency and excessive exposure can cause health issues. Maintaining a balanced diet typically provides sufficient manganese for most individuals; however, high levels of exposure can be toxic, particularly to the central nervous system. Chronic manganese exposure may result in a condition known as manganism, characterized by … Read more