Spectrometry

Lysosomal storage of drugs may influence cancer treatment outcomes

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One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, from a multi-disciplinary team led by Dr Louise Fets at the LMS, has mapped the distribution of a type of targeted treatments, known as PARP inhibitors, using advanced imaging techniques and patient ovarian tumour samples. The research reveals that build up of these drugs in lysosomes – small compartments inside cells that normally act as “recycling centres” – can trap and … Read more

Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation

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A novel nasal booster approach may help close the gap between systemic vaccination and infection-blocking mucosal immunity, offering fresh insight into next-generation COVID vaccine strategies.  Study: Intranasal booster drives class switching and homing of memory B cells for mucosal IgA response. Image Credit: Jo Panuwat D / Shutterstock Current intramuscular vaccines excel at eliciting blood-based … Read more

Early bone molecular changes signal osteoarthritis progression

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Osteoarthritis often goes undetected until cartilage damage is advanced, limiting treatment options. A new study shows that molecular changes in subchondral bone occur earlier and can signal disease progression before cartilage loss. Using spatial mass spectrometry imaging and synovial fluid proteomics, researchers identified bone-derived protein signatures beneath intact cartilage that were also detectable in joint … Read more

Early biomarkers predict infections after breast reconstruction surgery

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In the U.S., one in eight women will get breast cancer in their lifetime, and about half of them will have mastectomies. Many of those women opt to have their breasts surgically reconstructed, most commonly with implants, but a relatively high percentage develop infections after implant surgery, requiring intravenous antibiotics and often removal of the … Read more

Distinct tau chemical signatures redefine diagnosis across neurodegenerative diseases

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Tau protein aggregation is a shared feature in over 20 neurodegenerative diseases (collectively referred to as “tauopathies”). New research led by Boston Children’s Hospital challenges the current “one-size-fits-all” approach to diagnosing and treating these tauopathies. The team, led by senior authors Judith A. Steen, PhD, and Hanno Steen, PhD, and executed by co–first authors Mukesh … Read more

New analytical method enhances safety evaluation of metal-based nanomedicines

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Nanomedicines, especially those based on nanoparticles, are revolutionizing healthcare in terms of both diagnostics and therapeutics. These particles, often containing metals like iron or gold, can serve as contrast agents in medical imaging, act as nutritional supplements, and even function as carriers for drug delivery. Thanks to their unique properties plus careful engineering, nanomedicines can … Read more

Duke-NUS and NUS Medicine launch first-ever joint center to drive metabolomics research

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In a strategic move for medical research and innovation, Duke-NUS Medical School and the National University of Singapore Yong Loo Lin School of Medicine (NUS Medicine) have launched the Systems Metabolomics center (SysMeC), their first-ever joint research center. This groundbreaking initiative is set to drive cutting-edge metabolomics research, unlocking new ways to detect diseases earlier … Read more

Confocal-based high-content imaging in advancing core facilities

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In this interview, NewsMedical speaks with Arvonn Tully and Esther Kieserman from Yokogawa Life Science about how confocal-based high-content imaging is advancing core facility research and improving data reliability. Could you introduce yourselves and share your background, particularly your work with confocal-based high-content imaging and analysis? Esther Kieserman (EK): I have worked in the microscopy … Read more