Researchers at Indiana University in the United States recently tested gene therapy based on tissue nanotransfection as a treatment for muscle damage. During the experiments, they managed to reprogram the function of different tissues using a device in the form of a nanochip. This new process called tissue nanotransfection has notably been used as therapy for seven days in rats that suffered volumetric muscle loss. The test results were very encouraging. The researchers noticed that the muscle function sick animals improved thanks to this nanochip.
This minimally invasive device developed by researchers at Indiana University School of Medicine brings new hope to people who suffer from significant muscle damage. In particular, it could be a treatment for traumatic muscle loss. Previously, the same technology has already been used to transform skin tissue into blood or nerve cells.
The results of this study have been published in the journal Nature Partner Journals Regenerative Medicine.
Tissue nanotransfection has restored lost muscle functions
An individual presents a volumetric muscle loss following trauma or skeletal muscle surgery. This condition causes a decrease in muscle strength and a significant decline in mobility. Following this tissue loss, the muscle is no longer able to carry out its function. Losing just 20% of muscle mass can cause up to 90% physical disability. A person suffering from volumetric muscle loss thus displays a relatively poor quality of life.
However, the affected muscle is unable to regenerate on its own. Current clinical treatments for volumetric muscle loss are physical therapy or autologous tissue transfer. For its part, the new nanochip treatment has made it possible to restore effectively this lost muscle function. Nevertheless, although promising, it still needs to be developed.
Gene therapy offers a new approach for regenerative medicine
This news genetical therapy called tissue nanotransfection has the advantage of being minimally invasive. Once implanted in the patient, the nanochip sends harmless electrical impulses. It reprograms tissue function by delivering specific genes in a short time. These genes are known to be an important driver of muscle repair and regeneration.
These works are among the first to show interest of tissue nanotransfection in the treatment of volumetric muscle loss. In particular, they have opened up an avenue for research into the treatment of traumatic muscle loss. Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, said they demonstrate the versatility of the technological platform for tissue nanotransfection in regenerative medicine.
SOURCE : SCITECHDAILY