Researchers at the University of Birmingham have developed a new method for the EXPAR test without reverse transcriptase (RTF-EXPAR). The precise COVID-19 test will be the first to reduce the test time from half an hour to less than five minutes. The new method uses a binder DNA sequence that detects and binds to an enzyme that recognizes SARS-CoV-2 binder DNA and viral RNA and cuts a small section of it when viral RNA is present. Viral RNA is available to bind to other binder DNA once cleavage has occurred, and the cycle is repeated. The test detects the exit of this cycle. Professor Tim Dafforn from the University’s School of Biosciences said: “We have designed a new test method that combines the ease of use and speed of lateral flow testing with the sensitivity inherent in an RNA test. . It contains reagents that can be used in existing point-of-care devices and addresses the need for testing in high-throughput environments, close to the patient, where people can queue for their results.
“Researchers at the University of Birmingham have developed a five-minute COVID-19 test.”
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