Researchers at the University of Chicago have revealed the complete structure of adhesion GPCRs, uncovering new activation mechanisms that could lead to more targeted drug treatments.
Researchers at the University of Chicago have made a significant breakthrough in understanding adhesion G protein-coupled receptors (aGPCRs), a family of proteins vital for processes such as tissue growth, immune responses, and organ development. By capturing the full structure of aGPCRs and uncovering alternative activation mechanisms, this research opens up new possibilities for the development of targeted drugs.
Adhesion GPCRs, the second-largest family of GPCRs in humans, help cells adhere to one another and transmit signals throughout the body. They play an essential role in various biological processes, and…