Throughout the record-setting dengue virus outbreak in the Region of the Americas, the Republic of Nicaragua reported 92,022 cases in 2024.
According to a study published on January 10, 2025, all four virus serotypes impacted Nicaragua’s dengue outbreak. Based on 19 years of data from the Pediatric Dengue Cohort and Pediatric Dengue Hospital-based Studies in Managua, the relationship between serotype and immune status and dengue severity became very clear.
Of the 2,644 cases with serotype results by RT-PCR, 559 corresponded to DENV1, 1,002 to DENV2, 760 to DENV3, and 323 to DENV4.
Severe disease was more prevalent among secondary DENV2 and DENV4 cases, while similar disease severity was observed in both primary and secondary DENV1 and DENV3 cases.
These researchers wrote, ‘These findings…