The advanced of selenium and related compounds inhibiting multi-organ

Introduction

Se, a vital trace element for mammals, has a recommended daily intake ranging from a minimum of 55 µg to a maximum of 400 µg to maintain normal metabolism.¹ Se intake varies worldwide, with some regions in China experiencing both deficiencies and excesses.^2–4 Both Se deficiency and excess can lead to various diseases. Insufficient Se levels can elevate the risk of infections, cancers, cardiovascular diseases, neurological conditions, and other illnesses.⁵ Notable diseases associated with Se deficiency Keshan disease⁶ and Kashin-Beck disease.⁷ Excessive Se consumption can result in Se poisoning, which has been documented in regions such as Enshi, China,^4,8 California,⁹ Colorado^10,11 among others in the United States.¹¹ Symptoms of Se poisoning typically include vomiting, abdominal pain, and heart…