Endotoxins—those fever-inducing, sometimes life-threatening compounds—have haunted the pharmaceutical industry for over a century, since their discovery.
These potent substances, mainly bacterial endotoxins or lipopolysaccharides (LPS) from the outer membranes of gram-negative bacteria, are notorious for triggering severe reactions like fever and endotoxic shock when introduced into the human body. Their presence in drugs, medical devices, or lab consumables demands thorough screening to ensure safety.
Over the years, testing methods have evolved dramatically, moving from crude animal-based tests to cutting-edge synthetic alternatives that promise a future with less reliance on animals and more…