“Notably, high IGG expression, previously linked to reduced distant metastasis and extended survival, emerges as a reliable marker for extended longevity, signifying its role in sustaining antitumor immunity in survivors of breast cancer, and potentially other cancer types,” according to the study authors.
Use of a 14-gene B-cell/immunoglobulin (IGG) signature showed that high IGG signature expression significantly correlated with reduced mortality risks among survivors of breast cancer, according to findings from a study published in ESMO Open.1
Based on long-term follow-up data collected from 9638 patients with early-stage breast cancer, investigators reported a significant association between IGG expression and overall survival (OS) regardless of breast cancer subtype, tumor stage, or nodal status. This correlation…