Holders Celtic and city rivals Rangers were both handed home draws against second-tier opponents in the draw for the last 16 of the Scottish Cup.
Celtic will take on Raith Rovers, while Rangers host fellow Glasgow side Queen’s Park.
Speaking on Premier Sports immediately after the draw, Queen’s Park head coach Callum Davidson said: “Financially, it is great for the club to get a draw like that, but it will be a tough game for us.”
Three other Premiership sides will host Championship opposition.
Dunfermline Athletic visit Aberdeen, while St Johnstone, sitting bottom of the Premiership, will entertain Hamilton Academical.
And Dundee will take on Airdrieonians after becoming the final side to clinch their place in the fifth round with