Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumours may potentially be more susceptible to macrophage-based therapies.
The study which is published in Nature Communications was led by Associate Professor Shivan Sivakumar from the University of Birmingham and Associate Professor Rachael Bashford-Rogers at the University of Oxford and provides the most detailed immune map for pancreatic cancer. The findings suggest that some tumour cells are more likely to be infiltrated by T cell treatments, while others had myeloid cell infiltration. This means that cells such as macrophages could be suitable for future immunotherapeutic treatments in some cases.
Using cells from twelve patients, the research team created a single cell map of tumour infiltrating immune cells…