TOPLINE:
A 5-day high-caloric diet triggered liver fat accumulation and disrupted brain insulin action in men with a healthy body weight, with effects persisting even after resuming a normal diet. Researchers postulated that brain insulin responsiveness may adapt to dietary changes before weight gain, potentially facilitating the development of obesity.
METHODOLOGY:
- In healthy individuals, insulin signaling in the brain controls appetite and food intake, but in insulin-resistant states, this regulation is impaired, leading to increased visceral fat, poor metabolism, and greater fat regain after lifestyle changes.
- Researchers examined the effect of a 5-day high-caloric dietary intervention that incorporated widely available calorie-rich, ultraprocessed snacks alongside a regular diet on brain insulin action, body fat…