Higher fat content in the pancreas of children and adolescents with obesity is associated with an increased level of heart and metabolic risk factors, including higher than average body mass index (BMI), elevated diastolic blood pressure, higher levels of abdominal and liver fat, and insulin resistance, according to new research presented at this year’s European … Read more
When doctors review diagnostic medical scans for lung cancer, they sometimes spot abnormalities unrelated to the lungs. New research shows that some of those abnormalities could be signs of other undiagnosed cancers. The study, led by researchers at the Brown University School of Public Health, analyzed lung screening data from more than 26,000 people who took … Read more
A sweeping new review shows how disruptions in the gut microbiome may fuel obesity, insulin resistance, and cardiovascular risk, while pointing to diet and other microbiome-focused strategies that could help restore metabolic balance. Integrative mechanistic framework linking gut dysbiosis to systemic metabolic dysfunction. Arrows indicate the progression of events from exogenous and host-related factors to … Read more
Portal hypertension (PH), a serious complication of liver cirrhosis, is defined as a pressure gradient > 5 mmHg between the portal vein and the inferior vena cava. When the hepatic venous pressure gradient (HVPG) exceeds 10 mmHg, the condition becomes clinically significant, and complications rise substantially, making early detection critical for guiding treatment. A recent … Read more
Bottom Line: A machine learning model that analyzes patient demographics, electronic health record data, and routine blood test results predicted a patient’s risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, with high accuracy. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research … Read more
Metabolic-associated steatotic liver disease (MASLD) is a clinically heterogeneous condition with highly variable outcomes affecting more than 30% individuals globally. The disease is conventionally staged by histological progression, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and ultimately fibrosis or cirrhosis. Beyond liver-related outcomes, MASLD significantly elevates the risk of extrahepatic complications, including cardiovascular … Read more
iXCells Biotechnologies (“iXCells”), a leading provider of human cell-based solutions and custom iPSC services, today announced it has entered an international collaboration with Rosebud Biosciences (“Rosebud”), Kantify, and Incite to evaluate off-target chemotherapeutic toxicities in patient-specific organoids. Building on iXCells’ recent partnership with Rosebud and funded by Incite, the project will initially focus on predicting … Read more
A large real-world study shows that patients who stop popular GLP-1–based weight-loss drugs often return to treatment or try alternative therapies, helping explain why average weight regain after discontinuation may be smaller than expected. Study: Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide. Image credit: KaterynaBorodina/Shutterstock.com Obesity treatment has … Read more
Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution. Researchers are racing to use them to ferry therapeutic mRNA into cells for cancer therapies and treatments for inflammatory diseases, as well as delivering … Read more
A mouse study found that a father’s nicotine exposure can affect the offspring’s ability to process sugar and may contribute to diabetes risk, according to new research published in the Journal of the Endocrine Society. An estimated 40.1 million people in the United States have diabetes, according to the U.S. Centers for Disease Control and Prevention. Having diabetes … Read more