Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In Brazil, although no exact figures are available, it is estimated that between 10,000 and 12,000 new cases are diagnosed every year.
The disease, which accounts for nearly half (49%) of all brain tumors, has an extremely low survival rate, with most patients living only about 12 months after diagnosis. For this reason, scientists have been searching for new therapeutic targets for years to develop more effective treatments that can improve survival and quality of life for these patients.
Traditional treatment includes surgery to remove the tumor, chemotherapy, and radiotherapy. The main drug used is temozolomide…