Introduction
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by persistent synovitis and the destruction of joint cartilage and bone.1 Additionally, it affects the function of various organs, such as the heart, lungs, and kidneys, leading to a decline in quality of life.2,3 The prognosis of RA is influenced by early diagnosis and proper treatment.4,5 The biological and targeted synthesis disease modifying anti-rheumatic drugs (DMARDs) have been demonstrated to yield superior outcomes for patients suffering RA compared with conventional DMARDs. However, approximately 30%–40% patients have no response to the current treatment. Additionally, no treatment can be demonstrated to fully cure the disease.6 In accordance with the well-known heterogeneity…