The high comorbidity of type 2 diabetes (T2D) with psychiatric or neurodegenerative disorders points to a need for understanding what links these diseases. A potential link is the anterior cingulate cortex (ACC). The ACC supports behaviors related to cognition and emotions and is involved in some T2D-associated diseases, like mood disorders and Alzheimer’s disease (AD). James Hyman and colleagues, from the University of Nevada, Las Vegas, used a rat model of T2D that affects only males to explore whether diabetes affects ACC activity and behavior. Their work is featured in JNeurosci‘s Computational Properties of the Prefrontal Cortex Special Collection.
The researchers examined ACC activity and behavior as male rats sought rewards in a cognitively demanding maze. All rats pursued rewards, but areas…