TOPLINE:
A higher body mass index (BMI) across all ages as well as significant weight gain during adulthood were associated with a greater risk for renal cell carcinoma, while a BMI reduction of 10% or more in adulthood, especially after age 50 years, was associated with a lower risk for renal carcinoma, a new study showed.
METHODOLOGY:
- Excess body adiposity in midlife is a known risk factor for renal cell carcinoma; however, the association between lifetime body weight patterns and different subtypes of renal carcinoma remains largely unexplored.
- Researchers included 204,364 participants from the National Institutes of Health–American Association of Retired Persons Diet and Health Study and evaluated lifetime body weight patterns using BMI measured at age 18, 35, and 50 years and at baseline (age, 51-71 years).
- The BMI…