Cancer Vaccines Improve Their Aim

Cancer vaccines have been a tantalizing idea for decades, but the vast complexity of the human immune system has posed significant challenges. Now, technological advances like rapid DNA sequencing, lymph node targeting, and AI-informed antigen selection are enabling the creation of precision vaccines that target cancers effectively while minimizing harmful side effects.

Combating cancer’s immunosuppressive effects

Cancer Vaccines
Evaxion uses an AI platform to select 10 candidate neoantigens from a patient’s cancer that are most likely to generate a strong T-cell response, and use those antigens to develop a personalized vaccine. Evaxion’s vaccines are designed to work synergistically with checkpoint inhibitors, but could eventually be used as monotherapy.

One early cancer vaccine, developed in the late 1970s, was…

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