Microbiome dysbiosis—changes in the composition of gut microbes that alter the metabolites present—has long been implicated in playing a causative role in the pathophysiology of autism spectrum disorder (ASD). However, the changes in the gut microbial metabolites that are associated with ASD-specific brain alterations have remained unknown.
Now, a new study suggests that gut microbiome dysbiosis in children with ASD may create an imbalance of metabolites in the digestive system—ultimately disrupting neurotransmitter production and influencing behavioral symptoms. The researchers correlated metabolites with brain differences observed in children with ASD and their behavioral characteristics, homing in on the tryptophan pathway. The research adds to a growing body of science implicating the gut-brain…