Metabolomics

Maternal metabolic signatures at early gestation associated with birth weight and neurodevelopment in early childhood

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Sheng, C. et al. Maternal macronutrient intake at pregnancy and offspring growth trajectory through childhood: a prospective analysis in the Growing up Today Study 2 Cohort. American J. Clin. Nutrition https://doi.org/10.1016/j.ajcnut.2025.01.032 (2025). Mortaji, N. et al. Maternal pregnancy diet, postnatal home environment and executive function and behavior in 3- to 4-y-olds. Am. J. Clin. Nutr. … Read more

Machine learning model predicts liver cancer risk with high accuracy

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Bottom Line: A machine learning model that analyzes patient demographics, electronic health record data, and routine blood test results predicted a patient’s risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, with high accuracy. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research … Read more

Gut microbe molecules linked to coronary heart disease risk

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In a study involving data from thousands of people, the risk of a new coronary heart disease diagnosis was statistically associated with bloodstream levels of nine specific molecules that are produced by gut microbes. Danxia Yu of Vanderbilt University Medical Center, U.S., and colleagues present these findings on March 17th in the open-access journal PLOS … Read more

New review calls for biologically grounded approach to psychiatric diagnosis

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A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling. The review, authored … Read more

Nutri-Score labeling system fails to reflect nutritional complexity of cocoa

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Researchers at the University of Granada have revealed that the Nutri-Score labeling system, commonly used in Europe to assess food quality, is unable to adequately reflect the nutritional and metabolic complexity of soluble cocoa sold in Spain. The study, which is a pioneer internationally for integrating non-targeted metabolomics techniques applied to the evaluation of nutritional … Read more

Blood lipid–hormone ratios predict future asthma attacks years in advance

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Study: The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations. Image Credit: Prostock-studio / Shutterstock In a recent study in the journal Nature Communications, researchers analyzed medical records and blood samples from over 2,500 biobank participants with asthma to identify a novel predictive biomarker for future asthma exacerbations. The study used a metabolomics … Read more

Novel method predicts asthma exacerbations with high degree of accuracy

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Researchers at Mass General Brigham and Karolinska Institutet have identified a new method to predict asthma exacerbations with a high degree of accuracy. The study is published in Nature Communications. Asthma is one of the world’s most common chronic diseases, affecting over 500 million people. Asthma exacerbations – commonly known as asthma attacks – are … Read more

Metabolic profiling of frailty, associations with type 2 diabetes and interaction with genetic susceptibility | Cardiovascular Diabetology

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Study population Detailed information of the study design has been presented previously [15]. Briefly, the UK Biobank enrolled over 0.5 million participants aged 37 to 73 years from 22 sites across the UK between 2006 and 2010, and collected extensive information at recruitment, including data from touchscreen questionnaires, physical examinations, biological samples, and longitudinal follow-up for … Read more

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

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Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

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Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more