Researchers from the University of Cambridge and the NIHR Cambridge Biomedical Research Centre have created an algorithm that finds vulnerable cancer tumours
The new tool, PRRDetect, identifies cancer tumours with defective DNA repair mechanisms, potentially transforming how doctors determine which patients are more likely to respond successfully to cancer treatments. The study paper was published in Nature Genetics.
Researchers analysed the complete DNA sequence of 4,775 tumours
The researchers analysed the complete DNA sequence of 4,775 tumours from seven types of cancer. They used Genomics England’s 100,000 Genomes Project data to create an algorithm to identify cancer tumours with DNA faults.
The team looked for patterns in DNA created by indel mutations….