TOPLINE:
Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected monocytes, fibrocytes, and lymphocytes, leading to changes in gene expression and protein levels that may contribute to disease progression.
METHODOLOGY:
- Researchers examined CLL cell–derived exosomes and their effects on healthy donor cells, including monocytes, fibrocytes, and lymphocytes.
- Analysis focused on changes in gene expression and protein levels in target cells after exposure to CLL cell–derived exosomes.
- Investigation included assessment of monocyte CD14 and CD16 expression; T-cell checkpoint proteins, programmed cell death protein 1 (PD-1) and CD160; and B-cell apoptosis…