TOPLINE:
Vaccinating women with tetanus-diphtheria-acellular pertussis–inactivated polio virus (Tdap-IPV) during pregnancy in a sub–Saharan African setting was safe, well tolerated and boosted pertussis-specific antibody responses among infants in early life.
METHODOLOGY:
- Researchers conducted a phase 4 trial to assess the effect of pertussis vaccination during pregnancy on the immunogenicity of primary acellular or whole-cell pertussis vaccines in a West African cohort.
- A total of 343 women were enrolled between February 2019 and May 2021 and randomly assigned to receive either tetanus toxoid (n = 172) or Tdap-IPV (n = 171) during 28-34 weeks of gestation.
- Infants born to women in each group were subsequently randomly assigned to receive either the diphtheria-tetanus-acellular pertussis (DTaP) vaccine or the…