Summary: Infants hospitalized with severe COVID-19 mount an immune response that looks entirely different from that of adults or older children. Researchers found both interferon responses and inflammation were elevated simultaneously—something never before observed in other viral infections.
T and B cells in these infants were still naïve yet highly activated, and some even produced their own strong antibody responses, surprising scientists given their age. These findings suggest that infants’ immune systems operate on distinct principles and may require age-specific strategies for treatment and prevention.
Key Facts:
- Dual Activation: Infants showed simultaneous high interferon and inflammation—unusual in viral infections.
- Naïve but Active: Despite never encountering infection, infants’ T and B cells were…