Elevated cognitive frailty risk in older cancer patients
The study found that 26.7% of older cancer patients had cognitive frailty, which is higher than Ho MH et al. [7] (8.2%). Examining the underlying causes, cancer patients are susceptible to frailty due to the intricate effects of the cancer and the extensive treatments involved, including surgery and chemotherapy, which deplete physiological reserves [19]. Factors such as neurotoxicity, neuroinflammatory reactions, DNA damage from chemotherapeutic agents that penetrate the blood–brain barrier, and host-specific elements like genetic predisposition can contribute to additional cognitive decline [20]. This cognitive decline, in turn, can precipitate the onset of cognitive frailty. Additionally, cancer patients and their families often prioritize the tumor and its…