Introduction
The connection between the central and peripheral immune systems has garnered increasing research interest. Numerous studies have demonstrated a strong connection between central and peripheral immunity. Studies of the brain-spleen axis, lung-brain axis, and the association between atherosclerosis and the brain have revealed bidirectional regulation between the peripheral immune system and central nervous cells from various perspectives.1–4 The use of chemogenetics, optogenetics, and transgenic mouse models has further elucidated the functional links between central and peripheral inflammation.5,6 Koren et al demonstrated that, following an inflammatory storm, a “trace” remains in the central nervous system, enabling glutamatergic neurons in the insular cortex to retrieve and directly “encode”…