Fruquintinib Regimen in ESCC | Image
Credit: ©Ashling Wahner & MJH
Life Sciences Using AI
Frontline treatment with fruquintinib (Fruzaqla) plus camrelizumab, paclitaxel liposome, and nedaplatin elicited responses with an acceptable safety profile in patients with advanced esophageal squamous cell carcinoma (ESCC), according to findings from a phase 2 study (NCT06010212) presented during the 2025 ASCO Annual Meeting.
Among evaluable patients (n = 19), the confirmed objective response rate (ORR) is 68.4% (95% CI, 47.5%-89.3%) by RECIST 1.1 criteria, which was comprised entirely of partial responses; 31.6% of patients had stable disease. The disease control rate (DCR) was 100.0% (95% CI, 82.4%-100.0%). Moreover, at a median follow-up of 5.1 months (95% CI, 4.2-7.2), the median progression-free survival (PFS) was 8.7…